Hospital-associated MRSA genotypes causing complicated community-onset skin and musculoskeletal infections.

ABSTRACT:

Objectives

To assess clinical and epidemiological characteristics, and phenotypic and genomic risk factors associated with severity and death in complicated community-onset skin, soft tissue, and musculoskeletal infections (cSSTMIs) caused by methicillin-resistant Staphylococcus aureus (MRSA).

Methods

Patients with cSSTMIs were investigated between June 2022 to January 2024 and followed for one month after hospital discharge. Tissue samples were obtained through biopsy, punch, or fluid aspiration. All MRSA isolates underwent genomic sequencing. Factors associated with poor outcomes were analyzed using multivariate regression analysis, complemented by penalized regression (LASSO) with stratified cross-validation and sensitivity analyses to mitigate the risk of overestimation

SUBMITTER: Bazanelli Prebianchi S 

PROVIDER: S-EPMC12678274 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature