Comparison of two different bicarbonate replacement fluids during CVVH with RCA: a prospective, randomized, controlled trial.

ABSTRACT:

Purpose

This study aimed to compare a high (HBF) and low (LBF) bicarbonate (HCO₃^-) replacement fluid over 96 h after continuous veno-venous hemofiltration (CVVH) initiation using regional citrate anticoagulation to determine which fluid achieved better acid-base balance.

Methods

In this prospective, randomized, controlled, open-label, cross-over, single-center trial, patients were randomized to initially receive either LBF (22 mmol/l HCO₃^-) or HBF (30 mmol/l HCO₃^-) for 48 h (first phase), followed by changing to the other fluid for a further 48 h (second phase). Intracorporeal pH and HCO₃^- changes were analyzed by calculating the rates of levels outside the standard values (excursion rate

SUBMITTER: Perschinka F 

PROVIDER: S-EPMC12678463 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature