Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial.

ABSTRACT:

Purpose

To explore the association of frailty with mortality, functional outcome, and health status after out-of-hospital cardiac arrest.

Methods

This is a cohort-based secondary analysis of the Targeted Hypothermia versus Targeted Normothermia after out-of-hospital cardiac arrest (TTM2) trial, an international, prospective, multicentre study. Frailty was assessed using the Clinical Frailty Scale (1-9): fit (1-3), prefrail (4), frail (5), and severely frail (6-9). Main outcomes were mortality and poor functional outcome (modified Rankin Scale 4-6) at 6 and 24 months. Additional outcomes included neuroprognostication, withdrawal-of-life-sustaining-therapies (WLST), functional decline (retrospectively reported pre-arrest versus 6 month Glasgow Outcome Scale Extended score), he

SUBMITTER: Gobel Andertun S 

PROVIDER: S-EPMC12678506 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature