ZNF217 promotes ovarian cancer progression by impacting multiple pivotal steps in the metastatic process.

ABSTRACT: Ovarian cancer is characterized by aggressive metastasis, chemoresistance, and poor survival outcomes. Gaps in understanding of factors that drive these phenotypes have hindered the development of actionable therapeutic targets. We demonstrate that Zinc Finger Protein 217 (ZNF217) is a key pro-metastatic factor in ovarian cancer cells. ZNF217 overexpression dramatically increases proliferation, metastasis, and chemoresistance while its depletion impairs these phenotypes. Consistently, ZNF217 overexpression is associated with poor prognosis in both mouse models and ovarian cancer patients. Interestingly, ZNF217 induces metastatic phenotypes in fallopian tube cells, suggesting potential role in the transition of early-stage tumors to aggressive carcinoma. ZNF217's oncogenic activity is depen

SUBMITTER: Wardrup KC 

PROVIDER: S-EPMC12678582 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature