FAM172A promotes epithelial ovarian cancer progression and induces platinum resistance via the PI3K/AKT pathway.

ABSTRACT: This study aimed to investigate the role of FAM172A in epithelial ovarian cancer (EOC), a highly lethal gynecological malignancy often diagnosed at late stages with limited treatment options. FAM172A expression was evaluated in EOC and normal ovarian tissues using western blotting and immunohistochemistry, and its association with patient prognosis, treatment response, and CA125 levels was assessed by multivariate regression analysis. Functional assays were performed to examine the effects of FAM172A on EOC cell proliferation, migration, and invasion. In vivo models were used to evaluate the influence of FAM172A on tumor growth, metastasis, and chemosensitivity. The underlying mechanism was explored by modulating the PI3K-Akt pathway with pharmacological inhibitors and activators. FAM172A

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12678607 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature