Efficacy and safety of repetitive transcranial magnetic stimulation in youth with depression: a systematic review and meta-analysis of randomized sham-controlled trials.

ABSTRACT:

Background

Major depressive disorder is a major cause of disability and health-related burden globally. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for major depressive disorder in adults, but its efficacy and safety in 10-25 years (youth) with depression remains inconclusive. We aim to evaluate the efficacy and safety of rTMS in youth with depression in randomized sham-controlled trials.

Methods

A comprehensive search of nine databases was conducted from inception to April 30, 2025. Trials using random assignment with a sham control group were selected. Heterogeneity among studies was assessed using the I² and Cochran Q test. A random-effects model was employed when I² > 50%. Standard mean deviatio

SUBMITTER: Tao YJ 

PROVIDER: S-EPMC12678628 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature