Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study.

ABSTRACT:

Background

Cardiac arrhythmias pose a major health concern while the role of antidiabetic medications in cardiac arrhythmic risks is not fully understood.

Method

We conducted a two-sample Mendelian Randomization (MR) analysis using genetic instruments extracted from hemoglobin A1C (HbA1c) as proxies for antidiabetic drug targets to evaluate their causal relationship with five cardiac arrhythmias derived from the Finngen database. Summary-data-based Mendelian randomization (SMR) utilizing gene expression data from the eQTLgen consortium was further employed to assess the role of antidiabetic drug targets in cardiac arrhythmias from the gene expression perspective.

Results

Three significant associations were identified. Sulfonylurea targets KCNJ11/ABCC8 were associated

SUBMITTER: Song ZQ 

PROVIDER: S-EPMC12678633 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature