Longitudinal assessment of brain volume and shape alterations in depressive patients with differential suicidality.

ABSTRACT:

Background and aims

In recent years, the study of brain structural changes in individuals experiencing suicidal ideation and depression has attracted increasing interest. This study investigated changes in gray and white matter volumes among different groups. We recruited 86 patients, including 26 healthy controls (HCs), 29 with depression (NS), 18 with suicidal ideation (SI), and 13 improved (IM), to further understand the impact of treatment on suicidal ideation.

Materials and methods

We used MRI to analyze four groups of participants at two time points over one-year intervals. Additionally, evaluations were conducted using clinical assessment scales (HAM-D, HADS-A, BSS, RRS).

Results

Repeated measures Analysis of Covariance (ANCOVA) and paired t tests revealed sign

SUBMITTER: Chen VC 

PROVIDER: S-EPMC12678688 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature