Hologenomic analysis of rectal mucus sampling for detection of adenomatous polyps and colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is the fourth most common cancer and the third leading cause of cancer-related mortality worldwide, with incidence rising among younger populations. The significant clinical and economic burden highlights the need for minimally invasive technologies capable of detecting pre-malignant and early-stage disease. Although liquid biopsy approaches have advanced, they have not achieved sufficient performance for clinical adoption when compared with colonoscopy, the current diagnostic gold standard. CRC is a mucosal pathology, yet current diagnostic methods have not leveraged mucosal biology. Here we demonstrate the clinical utility of rectal mucus specimens, collected using a minimally invasive device in an outpatient setting, without bowel preparation. Through a hologenom

SUBMITTER: Tock AJ 

PROVIDER: S-EPMC12678804 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature