Secretin targets interstitial cells of Cajal to regulate intestinal contractions.

ABSTRACT: Secretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by interstitial cells of Cajal (ICC). Transcripts of secretin receptors (Sctr) are expressed abundantly by ICC in the deep muscular plexus (ICC-DMP). Secretin inhibits small intestinal contractions in the presence of the neurotoxin, tetrodotoxin (TTX) and suppresses excitatory enteric neurotransmission. The inhibitory effects of secretin occur through inhibition of Ca²⁺ transients in ICC-DMP, likely via Gαs-coupled cAMP production and PKA activation that leads to inhibition of IP3 receptors. Our results provide a novel concept for the

SUBMITTER: Bartlett AM 

PROVIDER: S-EPMC12678811 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature