Skeletal muscle adiposity and cognitive decline in a biracial cohort: Insights from coronary artery risk development in young adults (CARDIA) study.

ABSTRACT:

Introduction

We examined skeletal muscle adiposity (myosteatosis), a risk factor for cardiometabolic diseases, and 5-year cognitive change in White and Black middle-aged men (n = 1080; 41.9% Black) and women (n = 1432; 49.0% Black).

Methods

Abdominal myosteatosis (intermuscular adipose tissue [IMAT, cubic centimeters]) was assessed by computed tomography at Year 25 (Y25). Cognition was assessed (Digit Symbol Substitution Test [DSST], Rey auditory verbal learning test [RAVLT], and Stroop test) at baseline and 5-year longitudinal follow-up (Y30). Multivariable linear regression assessed associations of IMAT with cognitive change.

Results

The 5-year change in all cognitive tests was significant: DSST of 2.8% (21.8), RAVLT 2.8% (17.5), and Stroop 6.5% (49.5). A greater Y2

SUBMITTER: Acevedo-Fontanez AI 

PROVIDER: S-EPMC12678840 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature