Effects of different electrical stimulation on depression: a protocol for systematic review and network meta-analysis.

ABSTRACT:

Objective

Depression is a common mental disorder characterized by persistent depressive mood, anhedonia, and diminished interest, severely impacting patients' quality of life and social functioning. Traditional treatments exhibit significant interindividual variability in efficacy, adverse reactions, uncertain long-term outcomes, high relapse rates upon discontinuation, prolonged treatment cycles, and substantial economic burdens. Electrical stimulation therapy represents a potential intervention, yet its efficacy and safety remain inconsistent across studies. This study aims to analyze the efficacy and safety of different electrical stimulation modalities in treating patients with depression, quantitatively assessing their comparative advantages and potential clinical benefits.

SUBMITTER: Yao S 

PROVIDER: S-EPMC12679154 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature