Multi-pathway-driven hepatic protection: Semaglutide combined with HIIT counteracts diabetic liver injury in db/db mice.

ABSTRACT:

Objective

Investigate the impact and mechanism of semaglutide (Sema) combined with high-intensity interval training (HIIT) on hepatic glucose/lipid metabolism in db/db mice using untargeted metabolomics.

Methods

Db/db mice were divided into model control, Sema alone, and Sema + HIIT groups, with db/m mice as controls. Sema (0.1 mg/kg/week) was administered subcutaneously, and the control group was subcutaneously injected with the same volume of distilled water. Engaging in HIIT swimming occurred for five consecutive days weekly. Weekly fasting plasma glucose (FPG), body mass, and food intake were assessed. After 8 weeks, blood/liver tissues were analyzed; liver metabolomics used LC-MS.

Results

Following an 8-week intervention, it was determined that the weight loss ef

SUBMITTER: Yu W 

PROVIDER: S-EPMC12679177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature