Preexposure Prophylaxis Prescription Dispensation Status and HIV-1 Acquisition.

ABSTRACT:

Importance

Preexposure prophylaxis (PrEP) is highly effective at preventing HIV-1 when taken as prescribed; however, barriers to uptake persist.

Objective

To assess clinical practice formulary coverage and PrEP uptake barriers and the association between those factors and cumulative HIV-1 incidence.

Design, setting, and participants

Retrospective observational cohort study from January 2021 to December 2023 using US pharmacy claims data from HIV-1-negative adults who received daily oral brand emtricitabine and tenofovir disoproxil fumarate (F/TDF), generic F/TDF (gF/TDF), or emtricitabine and tenofovir alafenamide fumarate (F/TAF), or intramuscular injection of cabotegravir every 2 months, for PrEP (after a 180-day washout period for previous PrEP use).

Exposures</

SUBMITTER: Tao L 

PROVIDER: S-EPMC12679327 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature