COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults Aged 18 to 59 Years in France.

ABSTRACT:

Importance

While several studies have assessed the impact of COVID-19 vaccination on short-term mortality, none have compared long-term mortality by vaccination status, particularly in young individuals who are less likely to experience severe disease following SARS-CoV-2 infection.

Objective

To compare 4-year all-cause mortality in individuals aged 18 to 59 years vaccinated with the mRNA COVID-19 vaccine vs unvaccinated individuals.

Design, setting, and participants

This cohort study used data from the French National Health Data System for all individuals in the French population aged 18 to 59 years who were alive on November 1, 2021. Data analysis was conducted from June 2024 to September 2025.

Exposure

Exposure was defined as receiving a first mRNA dose bet

SUBMITTER: Semenzato L 

PROVIDER: S-EPMC12679329 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature