Taste and Smell Disorders in Children and Young Adults With Cystic Fibrosis and Primary Ciliary Dyskinesia-A Prospective Comparative Study.

ABSTRACT:

Background

In cystic fibrosis (CF), the defect of the CF transmembrane conductance regulator (CFTR) can also affect sensory nerve cell function, as recently demonstrated in animal models. The aim of this prospective cohort study was to investigate whether taste and smell disorders in CF correlate with persistent CFTR dysfunction detectable by iontophoresis or rather with inflammation or lung function. Participants with primary ciliary dyskinesia (PCD) and controls without pulmonary disease served as comparators.

Methods

In 65 participants (age median 19 years IQR [12-26]; CF n = 23, PCD n = 22, controls n = 20) at the University Children´s Hospital Bochum, we measured taste (salty, sweet, sour, bitter) at four concentrations ("Taste-Strips," score 0-16, hypogeusia age-adjust

SUBMITTER: Beermann LC 

PROVIDER: S-EPMC12679337 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature