Vinyl ether maleic acid block copolymers: a versatile platform for tunable self-assembled lipid nanodiscs and membrane protein characterization.

ABSTRACT: Vinyl ether-maleic anhydride (VEMAn) copolymers were chain extended with n-butyl acrylate (nBA) and tert-butyl acrylate (tBA) blocks using reversible addition-fragmentation chain transfer (RAFT) copolymerization. Subsequently, the copolymers underwent hydrolysis to synthesize vinyl ether-maleic acid (VEMA) copolymers with different tail structures. The nBA block yielded VEMA extended with an acrylic acid (AA) block after hydrolysis. The tBA block gave VEMA extended with a mixture of tBA and AA blocks. This study investigates the effect of VEMA hydrophilicity/hydrophobicity and monomer structure in the second block on the formation and properties of self-assembled lipid nanodiscs. In particular, the size of the polymer-lipid discs and their i

SUBMITTER: Shah MZ 

PROVIDER: S-EPMC12679354 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature