"Electron transport chain interference" strategy of amplified bacterial ferroptosis and defect-engineered nanozyme for diabetic wound healing.

ABSTRACT: Background: The pathological hyperglycemic microenvironment in diabetic wounds increases susceptibility to bacterial infections and impairs wound healing. However, despite certain advancements in conventional clinical treatments, the pathological issues have not yet been fundamentally resolved. The mechanism that amplifies ferroptosis through disruption of the bacterial electron transport chain (ETC) results in effective bacterial eradication and facilitates wound healing, thereby offering novel therapeutic potential for the management of diabetic wound infections. Methods: This work designs a multi-enzyme-mimicking Fe-WS₂@GOx nanozymes by loading glucose oxidase (GOx) onto defect-engineered Fe-WS₂, which disrupts the bacterial ETC and induces ferroptosi

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12679372 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature