Serum Metabolomics for Prognostic Stratification in Resected Advanced-Stage Oral Cavity Cancer.

ABSTRACT:

Importance

Improved methods are needed to predict recurrence in oral cavity squamous cell carcinoma (OCSCC). However, to date, no metabolome studies have fully explored the prediction of OCSCC relapse patterns and survival.

Objective

To identify serum metabolites associated with OCSCC recurrence and develop and validate a prognostic scoring system.

Design, setting, and participants

This retrospective cohort study was conducted at a single tertiary academic center and enrolled patients with histologically confirmed, surgically resected first primary advanced-stage OCSCC from betel quid-chewing areas. Patients underwent primary surgery between February 2007 and May 2018, with follow-up data systematically collected through a prospectively maintained institutional regist

SUBMITTER: Shen EY 

PROVIDER: S-EPMC12679420 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature