The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition.

ABSTRACT: AMP-activated protein kinase (AMPK) acts as a central cellular sensor at the interface of metabolic and signaling networks, that supports cell survival in energetically unfavorable environments. Due to its role in the direct mediation of fatty acid oxidation via acetyl-CoA carboxylase 2 (ACC2), there has been intensive development of small molecule AMPK activators for the treatment of metabolic diseases, such as diabetes and non-alcoholic fatty liver disease. In cancer, AMPK inhibitors may be more effective in disrupting catabolic processes that support cancer cell survival and drug resistance. We have previously reported a structure-activity study of substituted oxindoles based on the multi-kinase inhibitor sunitinib to determine the structural requirements for AMPK inhibition and

SUBMITTER: Strang JE 

PROVIDER: S-EPMC12679472 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature