Bulky alkali metal cations enabled highly efficient iridium-catalyzed asymmetric hydrogenation for C-N axial chirality via dynamic kinetic resolution.

ABSTRACT: The addition of excess alkali metal to Noyori-type catalysts (HM-NH) generates anionic species (HM-NM'), which significantly enhances both the reaction rate and turnover number (TON) in asymmetric hydrogenation. However, such anionic catalysts have been largely confined to the construction of central chirality, with few reports on application to axial chirality. Herein, we report a highly efficient anionic iridium catalyst (HIr-NCs) based on a newly tridentate ligand framework (Huaphos), which enables the asymmetric hydrogenation of N-aryl indole ketones (and aldehydes) via dynamic kinetic resolution under mild conditions, allowing for the construction of axial chirality with excellent stereocontrol (up to >99% ee and >99 : 1 dr). DFT studies indicate that strong electrostati

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12679508 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature