Removal of Porcine Endogenous Retroviruses in Decellularized Liver Bioscaffolds.

ABSTRACT: Tissue engineering using decellularized liver scaffolds presents a promising approach in regenerative medicine, offering a potential alternative to donor organ transplantation. The use of human livers as a bioscaffold is restricted by their limited availability and quality. Porcine livers offer an alternative due to their anatomical and physiological similarities to human livers. However, applying porcine-derived biomaterials in a clinical setting poses a risk of pathogen transmission, which is a noteworthy concern. Porcine endogenous retroviruses (PERVs), which are integrated into the genome of all pig breeds, are of particular concern, as subclasses PERV-A and PERV-B have shown to infect human cells in vitro. It is therefore essential to effectively remove all PERVs when manufacturing po

SUBMITTER: van Hengel EVA 

PROVIDER: S-EPMC12679514 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature