Thin-Film Reference Electrodes for Fast-Scan Cyclic Voltammetry.

ABSTRACT: Electrochemical sensors rely on reference electrodes (REs) to provide stable potential standards, ensuring accurate and reliable detection. The development of biocompatible, stable, and miniaturized REs to replace conventional Ag/AgCl electrodes is crucial for translating electrochemical sensing for human applications. This study evaluates the performance of thin-film electrodes made from gold (Au), platinum (Pt), poly(3,4-ethylenedioxythiophene)-polystyrenesulfonate (PEDOT:PSS), and platinum-iridium (Pt-Ir) as REs for fast-scan cyclic voltammetry (FSCV), a widely used technique for real-time neurotransmitter detection. Using dopamine (DA) sensing as a model platform, our results demonstrate that Pt-Ir electrodes provide the necessary stable potential, low drift, and high reproducibility f

SUBMITTER: Qi Y 

PROVIDER: S-EPMC12679531 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature