Association of <i>PLA2G2A</i> single nucleotide polymorphism and cardiometabolic diseases in an HIV-infected population.

ABSTRACT: While single nucleotide polymorphisms (SNPs) of the phospholipase A2 (PLA2) gene have been associated with cardiometabolic diseases (CMDs), such associations are yet to be demonstrated in a human immunodeficiency virus (HIV)-infected African population. Therefore, the association between SNPs of the PLA2 gene and CMDs in a South African population with HIV was investigated. This cross-sectional study included 716 participants recruited from HIV clinics in Cape Town, South Africa. Hardy-Weinberg equilibrium (HWE) was assessed for the SNPs investigated. CMDs were compared across the genotypes of the SNPs in HWE. Linear and logistic regression analyses, adjusting for age and sex were used to assess the risk of CMDs across the genotypes. Among the SNPs investigated, rs4744

SUBMITTER: Ndonwi EN 

PROVIDER: S-EPMC12679532 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature