Serotonin inhibits the influx of iron into cells by decreasing the expression of SLC11A2 in Caco-2 cells.

ABSTRACT: Iron is an essential trace element for biological functions and its homeostasis is strictly regulated. Intestinal iron absorption primarily occurs in the duodenum, and the iron transporter solute carrier family 11 member 2 (SLC11A2; also known as divalent metal transporter 1) is crucial in this process. Notably, iron absorption is regulated by iron stores in the body and hormones; however, the effects of serotonin on iron transport are poorly understood. The present study aimed to analyze the effects of serotonin on the expression and function of SLC11A2 using human colon carcinoma-derived Caco-2 cells. SLC11A2 mRNA and protein levels were measured using reverse transcription-quantitative PCR and western blotting, respectively. To investigate the effect of serotonin on intracellular iron c

SUBMITTER: Sugino Y 

PROVIDER: S-EPMC12679538 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature