Fine-Tuned Functionalizable Terpolymer Brush Nanocoating Resists Protein Adsorption and Bacterial Adhesion while Promoting Macrophage Activity and Osteoblast Proliferation.

ABSTRACT: Developing multifunctional biomaterial surfaces that resist biofouling while supporting cellular activity remains a significant challenge in biomedical engineering. We present a finely tuned functionalizable terpolymer brush nanocoating composed of zwitterionic carboxybetaine methacrylamide (CBMAA), sulfobetaine methacrylamide (SBMAA) and nonionic N-(2-hydroxypropyl) methacrylamide (HPMAA) with balanced antifouling cytocompatible characteristics through optimized surface hydration and charge. We analyzed chemical composition, thickness, ζ-potential, and wettability using X-ray photoelectron spectroscopy, infrared spectroscopy, spectroscopic ellipsometry, electrokinetic analysis, and water contact angle measurements. Systematic monomer ratio tuning identified poly(CBMAA 20 mol

SUBMITTER: Pilipenco A 

PROVIDER: S-EPMC12679544 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature