Transforming seafood waste into therapeutic potential: cholecalciferol-loaded marine bone as a biocompatible antimicrobial and biomedical therapeutic agent.

ABSTRACT: The seafood processing industry generates significant shell waste, such as cuttlefish bone (CFB), which poses environmental challenges but is rich in minerals suitable for biomedical applications. In this study, CFB was transformed into calcinated cuttlefish bone (CCFB) with a high specific surface area (92.64 m² g^-1) and pore volume (0.16 cm³ g^-1), enabling efficient loading of cholecalciferol (vitamin D3; 89.7% loading efficiency). Comprehensive characterization confirmed the structural integrity and adsorption capacity of the material. The incorporation of cholecalciferol into CCFB offered distinct functional advantages over CCFB alone. Cholecalciferol-loaded CCFB exhibited enhanced biocompatibility and great cytotoxic effect against the cance

SUBMITTER: Mahgoub SM 

PROVIDER: S-EPMC12679560 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature