LL-37-biofunctionalized titanium improves soft tissue seal surrounding the dental implant from the perspective of optimizing a race to the surface.

ABSTRACT: The bacterial oral environment poses a significant challenge to the long-term stability of dental implants due to vulnerability of peri-implant soft tissues to pathogenic infiltration. Therefore, the rapid formation of a dense soft tissue barrier in the transgingival mucosal area surrounding the implant is essential. In this study, we engineer a biofunctionalized titanium (Ti) material by leveraging polydopamine (PD) as an intermediate coating to immobilize the peptide LL-37 onto nanostructured Ti substrates (LL-37-PD@NT). Material characterization shows that LL-37 is successfully loaded onto Ti substrate, and although the roughness of LL-37-PD@NT increases within a certain extent, the overall biological activity is still better than that of smooth Ti, which is considered to be traditional

SUBMITTER: Li Y 

PROVIDER: S-EPMC12679594 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature