Dual Catalytic Enantioconvergent Carbamoylation of Aziridines.

ABSTRACT: Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12679628 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature