A Sterically Open Ruthenium-Based Photocage Activated by Red and Far-Red Light for a Wide Range of Drugs.

ABSTRACT: Herein we report a novel ruthenium-based photocage for photoactivated chemotherapy (PACT) that can deliver a variety of experimental and clinically approved anticancer drugs using red and far-red light. The new caging moiety is based on the polypyridine pentadentate ligand N⁶,N^6″-di(pyridin-2-yl)-[2,2':6',2″-terpyridine]-6,6″-diamine (baptpy), which once coordinated to ruthenium(II) can form the helically chiral [Ru(baptpy)(L)]X₂ prodrugs [6]Cl₂-[16]Cl₂. A total of ten active pharmaceutical ingredients (L) have been successfully conjugated to this photocage, including well-known agents such as Albendazole, Gemcitabine, Bosutinib, Neratinib, and Ponatinib

SUBMITTER: Husiev Y 

PROVIDER: S-EPMC12679631 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature