Anti-Inflammatory and Pro-Healing Effects of Human Plasma-Derived Exosomes in a Murine Wound Model.

ABSTRACT:

Background

Exosomes have emerged as key mediators in regenerative medicine because of their ability to facilitate intercellular signaling and promote tissue renewal. Exosomes from various origins have demonstrated efficacy in tissue regeneration.

Aims

To explore the potential of plasma-derived exosomes (PDEs) in wound healing through in vitro analyses and an in vivo mouse model.

Patients/methods

PDEs were isolated from blood and characterized using a nanoparticle assay. Human dermal fibroblasts (HDFs) were treated with PDEs at different concentrations to assess cell proliferation, migration, and gene expression. For in vivo evaluation, 8-mm full-thickness wounds were created on C57BL/6 mice and treated with either subcutaneous injection or topical smearing of PDEs at

SUBMITTER: Yang H 

PROVIDER: S-EPMC12679673 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature