Surgery-Induced Neutrophil Extracellular Traps Promote Tumor Metastasis by Reprogramming Cancer Cell Lipid Metabolism.

ABSTRACT: Cancer surgery is a double-edged sword, as it can induce an inflammatory response that promotes tumor recurrence and progression. In this study, we explored the effects of surgery-induced neutrophil extracellular traps (NET) in reprogramming cancer metabolism to foster metastatic tumor growth. To model the effect of surgery on tumor progression, mice bearing subcutaneous tumors underwent a midline laparotomy with mesenteric exploration for 30 minutes. Mice subjected to surgery showed accelerated primary subcutaneous and lung metastatic tumor growth. Perioperative inhibition of NET formation utilizing DNAse, GSK484, or peptidyl arginine deiminase 4 knockout mice prevented surgically induced tumor growth, whereas pretreating cancer cells with NETs in vitro before inoculation increased tumor

SUBMITTER: Haykal T 

PROVIDER: S-EPMC12679810 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature