Role of the gut microbiota in the pathogenesis and therapeutic approach to osteoporosis (Review).

ABSTRACT: Osteoporosis (OP) is a chronic systemic metabolic bone disease characterized by an imbalance between bone resorption and bone formation, resulting in a decrease in bone mass and density. Additionally, the deterioration of bone tissue microstructure increases the risk of fracture. This condition not only impairs the quality of life of patients but also threatens their safety. With the gradual aging of the population of China, the incidence of OP has been increasing annually, becoming a major public health issue threatening the health of middle-aged and elderly individuals, particularly women in these age groups. OP has garnered increasing attention due to its high prevalence and severe complications. OP has many triggering factors and a complex pathogenesis, which are currently considered t

SUBMITTER: Ao M 

PROVIDER: S-EPMC12679819 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature