Comparative effectiveness of hypoxia-inducible factor prolyl hydroxylase inhibitors versus erythropoiesis-stimulating agents on prognosis in non-dialysis chronic kidney disease: a propensity-matched cohort study.

ABSTRACT: Renal anemia in patients with stage-IV chronic kidney disease (CKD) is commonly treated with erythropoiesis-stimulating agents (ESAs), which are effective but associated with cardiovascular risks, variable responsiveness, and inflammatory complications. Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) have recently emerged as an alternative therapy that enhances endogenous erythropoietin production and improves iron metabolism. This retrospective cohort study utilized the TriNetX Global Collaborative Network to compare clinical outcomes between HIF-PHI and ESA users in non-dialysis stage IV CKD patients (estimated glomerular filtration rate 15-30 mL/min/1.73 m²). After 1:1 propensity score matching, 493 patients were included in each group and followed for up to

SUBMITTER: Hou YC 

PROVIDER: S-EPMC12679846 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature