Salivary and tonsillar microbiota across multiple sites in paediatric tonsillar hypertrophy and their associations with clinical factors.

ABSTRACT:

Background

Tonsillar hypertrophy (TH) and adenotonsillar hypertrophy (ATH) are primary risk factors for paediatric obstructive sleep apnoea (OSA), but their salivary microbiota differ.

Objective

This study aimed to investigate whether the tonsillar surface and core microbiota resemble the salivary microbiota, and whether these microbial profiles are influenced by adenoid hypertrophy and related clinical factors.

Design

Forty-nine children undergoing tonsillectomy were enrolled, including 21 children with TH and 28 with ATH. Saliva and tonsillar surface swabs were collected preoperatively, and core tissues were obtained intraoperatively. Microbiota were profiled via 16S rRNA sequencing, compared across sites and groups, and correlated with preoperative clinical indicat

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12679849 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature