Identification of candidate long non-coding RNAs and mRNAs associated with heart aging in mice.

ABSTRACT:

Background

Understanding the molecular mechanisms underlying cardiac aging may uncover novel therapeutic targets for age-related cardiovascular disease. Long non-coding RNAs (lncRNA), which regulate cell differentiation and disease progression, are emerging as promising diagnostic biomarkers and therapeutic candidates. However, their expression profiles and functional roles in the aging heart remain poorly characterized.

Methods

Male C57BL/6 wild type mice aged 20 months (aged group) and 3 months (young group) underwent transthoracic echocardiography to evaluate cardiac function. Myocardial aging phenotypes were assessed using hematoxylin-eosin, Masson's trichrome, terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL), and senescence-associated β-galacto

SUBMITTER: Kuai Z 

PROVIDER: S-EPMC12679924 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature