Loss of MFAP5 and Its Effect on Skin Homeostasis and Wound Healing.

ABSTRACT: MFAP5, also known as microfibrillar-associated glycoprotein-2 (MAGP2), may influence parameters of skin wound healing related to scar formation. To further elucidate its role in skin wound healing, we assessed skin wound repair in Mfap5^-/- mice. Loss of MFAP5 reduced external wound closure, angiogenesis, and enhanced neutrophil and macrophage wound influx. Loss of MFAP5 also reduced the deposition of total and mature collagen in uninjured normal skin (NS), but not in wounds. Furthermore, NS dermis of Mfap5^-/- mice was thinner without any reduction in tensile strength. Single-cell RNA-sequencing of NS and wounds from Mfap5^+/+ and Mfap5^-/- mice revealed two fibroblast subclusters that express MFAP5 more highly than other subclusters. Enrichment ana

SUBMITTER: Han C 

PROVIDER: S-EPMC12680048 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature