T-SCAPE: T cell immunogenicity scoring via cross-domain aided predictive engine.

ABSTRACT: T cell immunogenicity, the ability of peptide fragments to elicit T cell responses, is a critical determinant of the safety and efficacy of protein therapeutics and vaccines. While deep learning shows promise for in silico prediction, the scarcity of comprehensive immunogenicity data is a major challenge. We present T cell immunogenicity scoring via cross-domain aided predictive engine (T-SCAPE), a novel multidomain deep learning framework that leverages adversarial domain adaptation to integrate diverse immunologically relevant data sources, including major histocompatibility complex (MHC) presentation, peptide-MHC (pMHC) binding affinity, T cell receptor-pMHC interaction, source organism information, and T cell activation. Validated through rigorous leakage-controlled benchmarks, T-SCAPE

SUBMITTER: Kim J 

PROVIDER: S-EPMC12680054 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature