Multidimensional dynamic optical imaging unveils anesthetic-driven hemispheric lateralization in blood-brain barrier homeostasis.

ABSTRACT: The blood-brain barrier (BBB) is commonly known to be distributed evenly within the central nervous system. This study elucidates previously unexplored physiological phenomena associated with the spatial heterogeneity of the BBB. We found that isoflurane facilitates hemispheric lateralization in BBB permeability, leading to different responses between the left and right hemispheres. To substantiate this finding, we used neural optical imaging to comprehensively map the spatial homeostasis of BBB. Image segmentation and feature extraction exhibited hemispheric lateralization in vascular microstructure and function. Gait analysis confirmed that the lateralization of BBB homeostasis influences behavioral functions. Our results indicate that the left hemisphere enhances its self-protective mec

SUBMITTER: Li H 

PROVIDER: S-EPMC12680055 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature