Genoprevalence of cutavirus in benign and malignant intestinal and breast tissues.

ABSTRACT: Cutavirus (CuV), the newest human protoparvovirus (PPV), has gained attention due to its significant association with cutaneous T-cell lymphoma (CTCL) and its precursor, parapsoriasis, whereas the other human PPVs, bufavirus and tusavirus, show no such link. Given this association, it is important to investigate the prevalence of CuV DNA in other tissues, particularly those affected by malignancy or inflammation. This study assessed, by multiplex quantitative PCR, the genoprevalences of all three PPVs in 427 fresh-frozen intestinal biopsies from inflammatory bowel disease (IBD), colorectal cancer, adenomas or healthy mucosa of 185 individuals, as well as in 94 formalin-fixed paraffin-embedded (FFPE) biopsies from malignant and non-malignant breast conditions of 85 patients. The study also

SUBMITTER: Assimakopoulou IM 

PROVIDER: S-EPMC12680079 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature