Determinants of Exercise Intolerance in Postural Orthostatic Tachycardia Syndrome: A Systematic Review.

ABSTRACT:

Context

Postural orthostatic tachycardia syndrome (POTS) is characterized by increased heart rate (HR) with standing and is associated with dizziness, palpitations, and exercise intolerance, with poorly understood mechanisms.

Objective

To review the literature on cardiorespiratory fitness in POTS, and explore possible determinants of exercise intolerance.

Design

Systematic review of studies assessing exercise capacity in POTS.

Eligibility criteria

Eligible studies were original prospective and retrospective cohort studies and randomized controlled trials investigating formal exercise assessments (maximal exercise duration with or without gas exchange oxygen consumption (VO₂) measures) in patients with established POTS using standard criteria.

Stud

SUBMITTER: Hogwood AC 

PROVIDER: S-EPMC12680087 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature