Patterns of substance use in people with severe mental illness: A case-control study in Ethiopia.

ABSTRACT:

Background

Substance use disorders are increasingly prevalent in sub-Saharan African countries, with evident bidirectional risk for people with severe mental illness (SMI) resulting in more severe and chronic courses. This study examines the association between common substance use, including khat and alcohol, and SMI, comparing affected individuals to age and sex-matched controls in Ethiopia.

Method

This study uses data collected as part of the NeuroGAP-Psychosis project, a large multi-country case-control genetics study. This case-control study consisted of 6,500 people with severe mental illness and age and sex-matched 6,500 controls in Ethiopia. Current substance use was defined as any use within the last three months, while current regular use was defined as at least we

SUBMITTER: Alemayehu M 

PROVIDER: S-EPMC12680152 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature