The influence of type 2 diabetes and its metabolic correlates in middle-aged adults on cognition at mid and later life; A systematic review and meta-analysis.

ABSTRACT:

Introduction

While previous studies have examined the link between Type 2 Diabetes Mellitus (T2DM) and cognitive function in middle-aged adults, no review has explored the long-term effects on cognition of T2DM when diagnosed at midlife. This review aims to investigate any association between T2DM and its metabolic correlates during midlife and measures of cognitive function, spanning from midlife into later life.

Methods

Electronic databases (EMBASE, Medline, CINAHL, Web of Science) were explored from their establishment until December 2023 to identify studies exploring the link between T2DM in midlife (40-65 years) and cognitive function. T2DM was defined based on ESC and AHA criteria, encompassing diabetes status, FBG, HbA1c levels, and MetS presence. Cognitive function i

SUBMITTER: Joyce OC 

PROVIDER: S-EPMC12680190 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature