The SII-PNI score: A novel composite biomarker for personalized mortality risk prediction in peritoneal dialysis patients.

ABSTRACT:

Objective

Accurate risk stratification is crucial for personalized management in peritoneal dialysis (PD). This study aimed to develop and validate a novel biomarker, the SII-PNI score, integrating systemic immunoinflammatory index (SII) and prognostic nutritional index (PNI), for personalized mortality risk prediction in PD patients.

Methods

A retrospective cohort study analyzed data from 330 patients initiating PD between December 2005 and June 2023 at a single center. Patients were stratified into four risk groups based on median cut-off values for SII and PNI. The association between SII-PNI risk groups and mortality (all-cause, cardiovascular [CVD], infection-related) was assessed using Kaplan-Meier survival analysis and multivariable Cox proportional hazard models. The

SUBMITTER: Zhou M 

PROVIDER: S-EPMC12680217 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature