Ultrasensitive quantification of serum IFN-α and IFN-γ in systemic lupus erythematosus: A cross-sectional observational study.

ABSTRACT:

Background

Interferon (IFN) has been implicated in the pathogenesis of patients with systemic lupus erythematosus (SLE). However, its measurement in serum has been limited by low circulating levels that fall below the detection threshold of standard laboratory assays. In this study, we measured serum levels of IFN-alpha (IFN-α) and IFN-gamma (IFN-γ) using a novel ultrasensitive assay. We then aimed to analyze the relationship between these IFN levels and a broad spectrum of disease characteristics, including indices of disease activity and remission, and autoantibodies profiles.

Methods and findings

From an initial cohort of 400 patients, a total of 313 patients with SLE were recruited in this cross-sectional study from September 2023 to February 2024. A comprehensive charac

SUBMITTER: Gonzalez-Gay MA 

PROVIDER: S-EPMC12680241 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature