Trends in cognitive outcomes in middle-aged Americans across three birth cohorts.

ABSTRACT: Middle age is a key life course period for targeting modifiable risk factors for late-life cognitive decline. Although the prevalence of chronic conditions that are risk factors for cognitive impairment has increased in middle-aged adults since the 1990s, little is known about corresponding trends in cognitive trajectories and incidence of cognitive impairment. We conducted a cohort study of 7,852 participants ages 50-56 enrolled from 1998-2010 in the Health and Retirement Study (HRS) without cognitive impairment at baseline. Participants were followed biennially to examine cognitive trajectories and new-onset cognitive impairment by age 65, based on the HRS cognitive test battery. We used mixed effects models to examine change in cognitive scores and Cox regression models to compare incid

SUBMITTER: Brown RT 

PROVIDER: S-EPMC12680256 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature