Statistical methods to disentangle genetic effects influencing infertility and early fetal viability with a genome-wide application.

ABSTRACT: Genetic selection occurs at multiple stages before and during pregnancy. While parental genomes influence the probability of fertilization, the fetal genome, once established, plays a critical role in early fetal survival. However, when estimated separately, parental and fetal genetic effects may confound each other. To address this, we developed an extension of the case-parent triad design to jointly estimate the genetic contributions of the parents and the fetus. Our approach considers all offspring as carriers of the trait "fetal survival". As use of assisted reproductive technology (ART) usually reflects fertility issues, we performed separate analyses on non-ART and ART family units, hypothesizing that parental and fetal effects differ between these groups. In the Norwegian Mother, Fa

SUBMITTER: Skodvin SN 

PROVIDER: S-EPMC12680335 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature