Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.

ABSTRACT: Cardiac fibrosis is a pathological condition associated with many cardiovascular diseases. Atrial fibrosis leads to reduced atrial function, resulting in diminished blood flow and an increased risk of stroke. This reduced function arises from altered myocardial electrophysiological and mechanical properties. Identifying the relative importance of these fibrosis-associated properties can reveal the most significant determinants of left atrial function impairment. In this study, we used a computational framework to investigate the relative importance of various fibrosis-associated properties. Our model, a 3D electromechanical framework coupled with a 0D circulatory model, incorporated patient-specific geometries and fibrosis distributions from clinical imaging data. Nine parameters related t

SUBMITTER: Telle A 

PROVIDER: S-EPMC12680338 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature