DLK orchestrates a modular transcriptional response to axon injury with separate roles for Fos and Jun.

ABSTRACT: Axon injury initiates transcriptional reprogramming that in competent cells leads to regeneration. In vertebrate neurons, DLK acts upstream of Jun, STAT and Atf3, core transcription factors that mediate regeneration. It is unclear whether these three proteins are activated independently, or whether they function in a linear cascade. To investigate relationships between these transcription factors we wished to use Drosophila as a model system as it has one ortholog of each. However, the only transcription factor linked to DLK-mediated axon regeneration (AR) in flies was Fos. Using loss of function approaches we demonstrate that Jun, STAT and Atf3 are required for Drosophila sensory axon regeneration, indicating transcriptional control of axon regeneration is broadly conserved. We next inves

SUBMITTER: Mahata G 

PROVIDER: S-EPMC12680358 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature