Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival.

ABSTRACT: S-adenosylmethionine (SAM), produced by SAM synthases, is critical for various cellular regulatory pathways and the synthesis of diverse metabolites. Humans and many other organisms express multiple SAM synthases. However, loss of different synthase activity can have distinct phenotypic effects. For instance, in Caenorhabditis elegans loss of sams-1 leads to enhanced heat shock survival and increased life span, but loss of sams-4 reduces heat stress survival. This provides a biological context to test the hypothesis that the enzymatic source of SAM impacts its function and to identify mechanistic connections. Here, we show that SAMS-1 contributes SAM to a variety of intermediary metabolic pathways, whereas SAMS-4 has a more limited role to support SAM-dependent protein transmethylation rea

SUBMITTER: Munden AL 

PROVIDER: S-EPMC12680360 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature